Table 1.

Structural membrane parameters for the different amyloid ${\beta }_{25-35}$ concentrations. While the lamellar $d_z$-spacing changes with peptide concentration, the head group-head group distance $d_{HH}$ is constant such that changes can be attributed to changes in the water layer thickness, $d_{water}$. Distance between acyl chains ($a_T$), area per tail ($A_T$) and tail volume ($V_T$) continuously decrease with increasing peptide concentration while the disorder in tail packing increases ($\Delta a_T$). The membrane orientation parameter, f, decreases and lipid tilt angles increase, indicating and increasing distortion and bending of the bilayers with increasing peptides concentration. (Values from [21].)

A${\mathit{\beta }}_{\mathbf{25}\mathbf{-}\mathbf{35}}$ (mol%)	${\mathit{d}}_{\mathit{z}}$ (Å)	${\mathit{d}}_{\mathit{H}\mathit{H}}$ (Å)	${\mathit{d}}_{\mathit{w}\mathit{a}\mathit{t}\mathit{e}\mathit{r}}$ (Å)	${\mathit{a}}_{\mathit{T}}$ (Å)	$\mathbf{\Delta }{\mathit{a}}_{\mathit{T}}$ (Å)	${\mathit{A}}_{\mathit{T}}$ (Å${}^{\mathbf{2}}$)	${\mathit{V}}_{\mathit{T}}$ (Å${}^{\mathbf{3}}$)	$\mathit{f}$ Membranes	Lipid Tail Tilt (${}^{\mathbf{\circ }}$)
0	59.0 ± 0.1	39.4 ± 1.0	19.6 ± 0.5	5.20 ± 0.05	0.59 ± 0.02	23.4 ± 0.1	922 ± 1	0.96 ± 0.02	19.2 ± 5
3	54.9 ± 0.1	39.1 ± 1.0	15.8 ± 0.4	5.21 ± 0.05	0.61 ± 0.02	23.5 ± 0.1	919 ± 1	0.92 ± 0.03	21.4 ± 2.3
10	61.6 ± 0.4	39.2 ± 1.0	22.4 ± 0.6	5.21 ± 0.05	0.67 ± 0.02	23.5 ± 0.1	921 ± 1	0.90 ± 0.03	20.5 ± 2.3
20	58.0 ± 0.2	39.3 ± 1.0	18.7 ± 0.5	5.06 ± 0.05	0.74 ± 0.02	22.6 ± 0.1	886 ± 1	0.86 ± 0.03	25.4 ± 3