Table 2.
Base-case estimates of test performance data after MPP resolution [13].
| Cobas Test Results | Mutation Status Based on MPP Resolution | ||
| Mutation + | Wild Type | Total | |
| Mutation + | 151 | 2 | 153 |
| Wild Type | 3 | 276 | 279 |
| Total | 154 | 278 | 432 |
| Sensitivity: 98.1% Specificity: 99.3% Invalid rate: 8.9% | |||
| LDT Results | Mutation Status based on MPP Resolution | ||
| Mutation + | Wild Type | Total | |
| Mutation + | 149 | 6 | 155 |
| Wild Type | 5 | 272 | 277 |
| Total | 154 | 278 | 432 |
| Sensitivity: 96.8% Specificity: 97.8% Invalid rate: 15.6% | |||
MPP = Massively parallel pyrosequencing; LDT = Laboratory developed test.