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. 2017 Jul 7;7(3):52. doi: 10.3390/biom7030052

Figure 2.

Figure 2

Dynamic relocation of TORC1 is associated with its activity. When Gtr1 takes guanosine 5’-triphosphate (GTP) form, TORC1 is active and spread over the vacuole. When Gtr2 takes GTP form, TORC1 is inactive and concentrated on a punctuated structure on the vacuole. When TORC1 is active Atg (autophagy related gene) 13 is phosphorylated, and does not gather to preautophagosomal structure (PAS). When TORC1 is inactive, Atg13 is dephosphorylated and gathers to PAS. GDP; guanosine 5’-diphosphate.