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. 2017 Aug 4;7(3):59. doi: 10.3390/biom7030059

Figure 1.

Figure 1

Current model of the nutritional regulation of the cell cycle by the TORC1–Greatwall–Endosulfine–PP2A-B55 pathway. In nitrogen-poor media, PP2A-Pab1 is inactivated by the Ppk18–Igo1 pathway. Inactivation of PP2A-Pab1: (1) prevents the dephosphorylation of Cdk1–cyclin B target proteins, including Cdc25 and Wee1 (autocatalytic loop) leading to premature entry into mitosis; (2) prevents the dephosphorylation and inactivation of Gad8, leading to the extension of the G1 phase and sexual differentiation. TORC1: Tor complex 1. Sck1 and Sck2: S6 kinases. Ppk18: Greatwall. Igo1: Endosulfine. PP2A-Pab1: PP2A-B55. Gad8: Akt. Fkh2: Transcription factor forkhead 2.