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Significant metabolites identified in the heart 2 weeks after tyrosine kinase inhibitor (or vehicle control) treatment. PCA (principal components analysis) of metabolites identified in sunitinib-treated heart (A). t-test significant metabolites identified in sunitinib-treated heart (B). PCA (principal components analysis) of metabolites identified in erlotinib-treated heart (C). t-test significant metabolites identified in erlotinib-treated heart (D). N = 10/group.
