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Significant serum metabolites identified after 2 weeks of tyrosine kinase inhibitor (or vehicle control) treatment. PCA (principal components analysis) of serum metabolites from sunitinib-treated mice (A). t-test significant metabolites identified in serum from sunitinib-treated mice (B). PCA (principal components analysis) of serum metabolites from erlotinib-treated mice (C). t-test significant metabolites identified in serum from erlotinib-treated mice (D). N = 10/group.
