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. 2017 Sep 13;15(9):287. doi: 10.3390/md15090287

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Voltage-dependent effect of APETx4 on evoked K_V10.1 currents. (A) Normalized currents elicited in ND96 solution (2 mM K_o) were plotted versus the applied pulse potentials (mV) in control (●) and toxin condition (○). The data points were fitted with the Boltzmann equation; (B) Normalized currents elicited in HK solution (96 mM K_o) were plotted versus the applied pulse potentials (mV) in control (●) and toxin condition (○). The data points were fitted with the Boltzmann equation; (C) The inhibited current (%) observed after 1.6 µM APETx4 addition in ND96 (○) and HK (●) solution was plotted versus the applied pulse potentials; (D) Effect of APETx4 on the inactivation properties of K_V10.1. The non-inactivating channel fraction (I₂/I_2,max) was plotted against the corresponding prepulse potential (mV) in control (●) and toxin condition (○).