Skip to main content
. Author manuscript; available in PMC: 2017 Sep 28.
Published in final edited form as: J Bone Miner Res. 2015 Jul 14;30(11):2096–2102. doi: 10.1002/jbmr.2553

Table 1.

Association of Urinary Tract Stones With Annual Change in BMD

Urinary tract stones
na Yes Annual change (beta ± SE) No Annual change (beta ± SE) pa pb
Total hip 9717 −0.0013 ± 0.0003 −0.00113 ± 0.00006 0.57 0.33
  Sensitivity 1c 9446 −0.0012 ± 0.0003 −0.00114 ± 0.00006 0.91 0.49
  Sensitivity 2d 9717 −0.0012 ± 0.0003 −0.00114 ± 0.00006 0.90 0.48
Femoral neck 9717 −0.0007 ± 0.0003 −0.00087 ± 0.00007 0.50 0.49
  Sensitivity 1c 9446 −0.0009 ± 0.0003 −0.00087 ± 0.00007 0.99 0.96
  Sensitivity 2d 9717 −0.0009 ± 0.0003 −0.00087 ± 0.00007 1.00 0.97
Lumbar spine 9730 0.0046 ± 0.0004 0.00525 ± 0.00010 0.13 0.38
  Sensitivity 1c 9457 0.0042 ± 0.0005 0.00523 ± 0.00010 0.03 0.17
  Sensitivity 2d 9730 0.0042 ± 0.0005 0.00525 ± 0.00010 0.02 0.16
Whole body 9718 0.0030 ± 0.0003 0.00251 ± 0.00008 0.15 0.38
  Sensitivity 1c 9447 0.0029 ± 0.0004 0.00250 ± 0.00008 0.32 0.75
  Sensitivity 2d 9718 0.0029 ± 0.0004 0.00250 ± 0.00007 0.32 0.75

Coefficient of year (g/cm2 per year) in linear mixed model for BMD stratified on time-dependent urinary tract stone status. Linear mixed model was used to estimate beta coefficients and significance level.

a

Unadjusted; p value is test across slopes for those with kidney stones compared to those without.

b

Adjusted for age, race, BMI, physical functioning, age at menopause, education, income, region, smoking, fracture at age 55+ years, parent with fracture after 40 years old, general health, alcohol intake, diabetes history, hormone therapy use, physical activity, bisphosphonate, calcitonin, oral corticosteroids, antiepileptic, proton pump inhibitor, thiazide, loop diuretic, thyroid meds, HT arm, DM arm, CaD arm, and diet and supplement intake.

c

Sensitivity analysis 1: Including only women with baseline urinary tract stones (prevalent urinary tract stones) or never urinary tract stones (not incident).

d

Sensitivity analysis 2: Including the portion of longitudinal data for which urinary tract stones status did not change; this includes all the women in sensitivity analysis 1 and the initial data for women who developed urinary tract stones during study.