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| Outcome | Assumed risk | Source | Clinically important relative reduction | Sample size required1,2 |
| Active TB | 46/366 (13%) | Analysis 1.1 | 25% | 2990 |
| Death | 15/366 (4%) | Analysis 1.2 | 50% | 2282 |
1We based all calculations on: 2‐sided tests, with a ratio of 1:1, power of 0.8, and confidence level of 0.05. 2We performed all calculations using: sealedenvelope.com/power/binary‐superiority
