Table 1.
Effect of prebiotic treatments on aberrant crypt foci (ACF) in proximal, middle and distal colon in 1,2-dimethylhydrazine dihydrochloride (DMH)-initiated and non-initiated animals (n = 15).
| ACF | G1 (Basal Diet Control Group) | G2 (DMH Control Group) | G3 (DMH + GalOS 76 mg) | G4 (DMH + GalOS 114 mg) | G5 (DMH + GalOS 151 mg) | G6 (DMH + Inulin 114 mg) |
|---|---|---|---|---|---|---|
| ACF/proximal colon | ND | 27.4 ± 2.10 a | 24.7 ± 3.11 a,b | 18.7 ± 2.56 b,c | 14.3 ± 1.78 c | 16.4 ± 2.83 c |
| ACF/middle colon | ND | 44.7 ± 2.98 a | 42.3 ± 2.86 a,b | 34.3 ± 3.8 b,c | 22.9 ± 3.45 d | 28.3 ± 3.23 c,d |
| ACF/distal colon | ND | 119.1 ± 5.56 a | 115.3 ± 7.22 a,b | 110.4 ± 4.63 a,b | 101.7 ± 3.32 b,c | 90.3 ± 3.31 c |
| Total ACF/colon | ND | 191.2 ± 6.46 a | 182.4 ± 7.92 a | 163.4 ± 4.72 b | 139.0 ± 3.24 c | 135.1 ± 3.73 c |
| Percent inhibition of total ACF | - | - | 4.6 | 14.53 | 27.3 | 29.3 |
Values are expressed as Mean ± SE. Means in the same row with different superscript are significantly different (p ≤ 0.05). DMH, 1,2-dimethylhydrazine dihydrochloride (4 × 40 mg/kg b.wt., s.c.); ND, Not detected.