Figure 1.

Extract of Sheng-Mai-San (ESMS) ameliorated cardiac function and decreased myocardial injury in myocardial ischemia (MI)-induced heart failure (HF) mice. (A) Representative M-mode of echocardiograms. Cardiac performance was determined by echocardiography after three weeks of coronary artery ligation (CAL) in mice. The green peaks show the real-time change in the heart rate of the mouse; the yellow peaks indicate the real-time change of the body temperature; the long blue arrow indicates cardiac diastole; and the short white arrow shows cardiac systole; (B) Left ventricular (LV) ejection fraction changes; (C) LV fractional shortening changes; (D) The release of: lactate dehydrogenase (LDH), (E) creatine kinase (CK), (F) brain natriuretic peptide (BNP) were determined in serum after three weeks of CAL in mice (n = 8). Results were presented as mean ± SD. Bsp = Bisoprolol (positive control).