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. 2017 Aug 25;18(9):1825. doi: 10.3390/ijms18091825

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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ESMS inhibited myocardial apoptosis in MI-induced HF mice. (A) Representative photomicrographs of terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL) staining images. The region of peri-infarcted was analyzed, and the arrow indicates apoptotic nuclei. Bar is 50 μm; (B) Quantitative analysis of apoptotic cells in TUNEL staining (n = 6); (C) Caspase-3 activity of all groups were determined in tissue after three weeks of CAL in mice (n = 8). Results were presented as mean ± SD. Bsp = Bisoprolol (positive control).