Figure 4.

Effect of rebamipide on IL-8 release induced by LPS in human corneal fibroblasts. Cells were incubated first for 1 h with the indicated concentrations of rebamipide and then for 48 h in the additional absence (open circles) or presence either of LPS (100 ng/mL, triangles) plus 0.5% human serum or of tumor necrosis factor-α (TNF-α) (10 ng/mL, closed circles), after which the concentration of IL-8 in culture supernatants was determined. Data are means ± SEM of quadruplicates from a representative experiment. ** p < 0.01 versus the corresponding value for cells incubated without rebamipide. Reprinted with permission from [42].