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. 2017 Aug 23;18(9):1831. doi: 10.3390/ijms18091831

Figure 5.

Figure 5

Effects of LL37 on LPS- or TNF-α–induced IL-8 and ICAM-1 expression in human corneal fibroblasts. Cells were incubated first for 2 h with the indicated concentrations of (A) or 1 µM (B) LL37 and then for 48 h (A) or 24 h (B) in the additional presence of LPS (100 ng/mL) plus 0.5% human serum (closed circles), of 0.5% human serum alone (open circles), or of TNF-α (10 ng/mL, triangles). The concentration of IL-8 in culture supernatants (A) and the cell surface expression of ICAM-1 (B) were then determined. ** p < 0.01 versus the corresponding value for cells incubated without LL37 (A). ** p < 0.01 versus the corresponding value for cells incubated with 0.5% serum alone; †† p < 0.01 versus the corresponding value for cells incubated without LL37 (B). Reprinted with permission from [56].