Figure 1.

Effects of monocarboxylate transporter (MCT) inhibition by α-cyano-4-hydroxycinnamic acid (4-CIN) on stimulus induced extracellular tissue oxygen changes (ΔpO₂), field potential responses (FP), amplitude and recovery kinetics of extracellular K⁺ concentration changes (Δ[K⁺]_O). Despite the clear effect on the stimulus induced pO₂ changes neither recovery kinetics of Δ[K⁺]_O nor field potential amplitude were affected by 4-CIN. (A) Sample traces of ΔpO₂ (left), field potential transients (middle) and Δ[K⁺]_O (right) in the presence and the absence of 4-CIN. Inhibition of the MCTs decreased ΔpO₂ both at (B) 200 µM and (C) 500 µM 4-CIN concentration, (D,E) whereas it did not affect field potential amplitude and (F,G) first half recovery time of Δ[K⁺]_O for both concentrations, respectively; (B–G) Variables are given on the Y-axis, categories of treatment on the X-axis. *** p < 0.001.