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Stability assays of VA- and VC-based conjugates in PBS. Compound in phosphate buffered saline (PBS) (pH 7.4) were incubated at 37 °C for seven days. Error bars represent standard deviation from three independent experiments (triplicates). Results are shown as the mean ± SD. (A) Stability of NAC-12b and NAC-12c; (B) Stability of VA- and VC-based ADCs loaded with four and seven drugs per antibody.
