Figure 6.
Cytotoxicity and selectivity of ADCs in tumor cells in vitro. Cytotoxicity assay performed in HER2-positive, weakly positive and negative cell lines. Breast cancer cell lines BT-474 and SK-BR-3, gastric cancer cell line NCI-N87, and ovarian cancer cell line SK-OV-3 were HER2-positive. Breast cancer cell lines MCF-7 and MDA-MB-468 were HER2-weakly positive and -negative, respectively. Each group was established three holes and results are shown as mean ± SD. IC50 is presented on Table 1.