Table 1.

Cytotoxicity of ADCs, antibodies and MMAE in cancer cell lines in vitro.

Cell Line	HER2 Status	IC50 (nM)
		mil40-12a	mil40-12b	mil40-12c	mil40	Herceptin	MMAE
BT-474	HER2+	0.09	0.08	0.08	1.54	1.75	0.30
SK-BR-3	HER2+	0.02	0.02	0.02	0.27	0.19	0.12
NCI-N87	HER2+	0.05	0.06	0.05	0.36	0.43	0.16
SK-OV-3	HER2+	0.22	0.15	0.16	2762.61	>2703	0.64
MCF-7	HER2−	232.47	166.71	721.79	>3438	>2703	0.22
MDA-MB-468	HER2−	523.12	468.85	606.28	552.55	1558.71	0.07