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. 2017 Aug 30;18(9):1873. doi: 10.3390/ijms18091873

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of I_K1 injection on the action potential of hiPSC-CMs. (A,B) Action potential of (A) a CTRL and (B) an RA-treated hiPSC-CM in the absence and presence of a synthetic I_K1, which is computed in real time according to the current–voltage relationship of Figure 2B and supplied through the patch-camp pipette. Insets: time derivative of the AP upstroke. (C,D) Corresponding dynamic clamp current injected into the cell. The sharp cut-off peak of 3 ms duration starting at 5 ms represents the stimulus current, which is applied at 1 Hz.