Table 4.
Action potential parameters of hiPSC-CM model cell upon injection of synthetic IK1.
| Action Potential Parameter | Meijer van Putten et al. IK1 | Rocchetti et al. IK1 | Bett et al. IK1 | |||
|---|---|---|---|---|---|---|
| Vent | Atr | Vent | Atr | Vent | Atr | |
| MDP (mV) | −83.9 | −84.0 | −79.5 | −79.4 | −82.2 | −82.8 |
| Vmax (V/s) | 129.1 | 209.6 | 87.0 | 149.8 | 130.4 | 210.0 |
| APA (mV) | 134.8 | 138.2 | 120.3 | 129.2 | 132.1 | 136.2 |
| AP plateau (mV) | 112.4 | 110.8 | 107.0 | 106.0 | 101.7 | 100.4 |
| APD20 (ms) | 30.8 | 20.8 | 42.4 | 31.5 | 14.8 | 8.7 |
| APD50 (ms) | 240.9 | 135.1 | 248.5 | 138.3 | 94.8 | 65.8 |
| APD90 (ms) | 306.6 | 183.3 | 311.5 | 189.6 | 144.4 | 96.5 |
Data obtained with ventricular-like and atrial-like hiPSC-CM model cells of Paci et al. [30,31]. Vent: ventricular-like cell; Atr: atrial-like cell; MDP: maximum diastolic potential; Vmax: maximum upstroke velocity; APA: action potential amplitude; AP plateau: AP plateau amplitude; APD20, APD50, and APD90: action potential duration at 20%, 50%, and 90% repolarisation, respectively.