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. 2017 Sep 11;18(9):1945. doi: 10.3390/ijms18091945

Figure 7.

Figure 7

SH suppresses the growth of human glioblastoma tumors in vivo. (A) Body weight and (B) tumor volume were recorded every 2–3 days; (C) Images of tumors are shown; (D) Tumor weight was assessed on the fifteenth day after U87 cell implantation. (E) Immunohistochemical staining of cleaved caspase-3, LC3B, p62, cathepsin B and cathepsin D in tumor sections treated with physiological saline or SH (150 mg/kg). The panels are representative overview images taken at 400× magnification, with the exception of the immunohistochemical staining of LC3B (1000× magnification); (F) The indicated proteins from transplanted mouse U87 human glioblastoma tissues were examined via Western blotting. β-actin was used as the loading control. Data are represented as the mean ± SEM of seven mice in each group. * p < 0.05, ** p < 0.01, SH-treated group compared with the control group not treated with SH.