. 2017 Sep 13;18(9):1964. doi: 10.3390/ijms18091964

Table 4.

Polyphen-2 results and domain localization of the selected mutations.

Mutation	Score	Confidence	Domain	Prediction
R61W	0.773	Sensitivity: 0.76	EGF-like 1	Possibly damaging
R61W	0.773	Especificity: 0.86	EGF-like 1	Possibly damaging
R75P	0.884	Sensitivity: 0.71	EGF-like 1	Possibly damaging
R75P	0.884	Especificity: 0.89	EGF-like 1	Possibly damaging
D80G	0.694	Sensitivity: 0.78	EGF-like 2	Possibly damaging
D80G	0.694	Especificity: 0.85	EGF-like 2	Possibly damaging
R213K	0.171	Sensitivity: 0.89	EGF-like 5	Benign
R213K	0.171	Especificity: 0.72	EGF-like 5	Benign