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Kinetic constants and binding affinities of IRCR201.
| Proteins | Ka (1/Ms) | Kd (1/s) | KD (nM) |
|---|---|---|---|
| Human c-Met ECD-Fc | 4.226 × 106 | 3.045 × 10−3 | 0.7207 |
| Mouse c-Met ECD-Fc | 3.826 × 106 | 3.232 × 10−3 | 0.8448 |
Ka and Kd were measured by a Biacore™ T100 using purified IRCR201, and KD was calculated by Biacore™ evaluation software. Abbreviations: Ka, association rate constant; Kd, dissociation rate constant; KD, equilibrium dissociation constant.
