Table 1.

Upregulated miRNAs at 24 h after treatment with hydromorphone or oxycodone.

Hydromorphone (N = 6)			Oxycodone (N = 23)
miRNA	ΔCq(24 h–Pre)	q-Value	miRNA	ΔCq(24 h–Pre)	q-Value
hsa-miR-127-3p	−2.85	0.003	hsa-miR-361-3p	−1.18	0.005
hsa-miR-182-5p	−1.87	0.044	hsa-miR-208a	−0.89	0.003
hsa-miR-339-5p	−1.47	0.006	hsa-miR-339-3p	−0.69	0.027
hsa-miR-374b-5p	−1.39	0.003	hsa-miR-10b-5p	−0.62	0.002
hsa-miR-28-5p	−1.33	0.009	hsa-miR-28-3p	−0.59	0.042
hsa-miR-551b-3p	−1.33	0.008	hsa-miR-125a-5p	−0.51	0.004
hsa-let-7d-5p	−1.25	0.003	hsa-miR-342-3p	−0.49	0
hsa-miR-26a-5p	−1.15	0.009	hsa-miR-150-5p	−0.48	0.001
hsa-miR-382-5p	−1.09	0.037	hsa-miR-146b-5p	−0.46	0.005
hsa-let-7f-5p	−1.05	0.018	hsa-miR-197-3p	−0.40	0.01
hsa-miR-154-5p	−1.01	0.039	hsa-miR-146a-5p	−0.40	0.001
hsa-let-7e-5p	−1.00	0.042	hsa-miR-23b-3p	−0.38	0.001
hsa-miR-191-5p	−0.98	0.013	hsa-miR-221-3p	−0.36	0.027
hsa-miR-103a-3p	−0.95	0.004	hsa-miR-23a-3p	−0.33	0.001
hsa-miR-423-3p	−0.91	0.004	hsa-miR-199a-3p	−0.32	0.031
hsa-miR-1	−0.87	0.043	hsa-let-7a-5p	−0.29	0.027
hsa-miR-766-3p	−0.84	0.04	hsa-miR-29a-3p	−0.29	0.027
hsa-let-7a-5p	−0.80	0.009	hsa-miR-223-3p	−0.27	0.011
hsa-miR-181a-5p	−0.79	0.035	hsa-miR-24-3p	−0.25	0.001
hsa-miR-199a-3p	−0.77	0.003	hsa-miR-142-3p	−0.24	0.011
hsa-miR-146a-5p	−0.75	0.004	hsa-miR-423-3p	−0.23	0.038
hsa-miR-328	−0.73	0.002	hsa-miR-126-3p	−0.17	0.033
hsa-let-7c	−0.73	0.019
hsa-miR-221-3p	−0.67	0.012
hsa-miR-151a-5p	−0.67	0.009
hsa-miR-142-5p	−0.63	0.026
hsa-miR-24-3p	−0.61	0.005
hsa-miR-324-5p	−0.60	0.035
hsa-miR-107	−0.60	0.022
hsa-miR-151a-3p	−0.60	0.011
hsa-miR-23b-3p	−0.58	0.005
hsa-miR-146b-5p	−0.56	0.035
hsa-miR-223-3p	−0.52	0.02
hsa-miR-652-3p	−0.49	0.006
hsa-miR-140-5p	−0.41	0.043

miRNAs upregulated upon hydromorphone and/or oxycodone treatment are presented. Underlined miRNAs are commonly upregulated between both hydromorphone and oxycodone. q-values are FDR adjusted p values of paired t-test between Pre and 24 h.