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. 2017 Sep 16;18(9):1997. doi: 10.3390/ijms18091997

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Diagram of the signaling pathways of the activated NKG2D receptor complex through DAP10. Cytokines are presented in diamond shapes, signaling proteins in ovals, ions in hexagons and cellular effects in rectangles. DAP10 (DNAX-activating protein of 10 kDa); IL-15 (interleukin 15); Grb2 (Growth factor receptor-bound protein 2); P85 PI3K (P85 subunit of PhosphoInositide 3-Kinase); Vav-1 (vav guanine nucleotide exchange factor 1); MEK (Mitogen-activated protein kinase kinase); ERK (Extracellular signal-Regulated Kinase); JNK (c-Jun N-terminal protein Kinases); cJunN (c-Jun N-terminal kinase-1); SLP-76 (SH2 domain-containing leukocyte phosphoprotein of 76kDa); CA++ (Ca²⁺ ion); PLCγ2 (Phospholipase C γ-2); Akt (Protein Kinase B); JAK2 (Janus kinase 2); STAT5 (Signal Transducer and Activator of Transcription 5).