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. 2017 Sep 20;18(9):2013. doi: 10.3390/ijms18092013

Figure 5.

Figure 5

Neurite outgrowth of clinical patient derived OV on the 2D scaffold. Human iPSCs from patient with clinical optic nerve degenerative disease are differentiated into OVs and seed on two-dimensional scaffolds. (a) The patient cell’s neurite outgrowth on two-dimensional scaffold (button panel) and without two-dimensional scaffold (top panel). The length of the RGC nerve bundle without the scaffold is about 522 ± 32 μm. The length of the RGC nerve bundle with a 2D scaffold is about 1093 ± 53 μm, which is significantly longer (p < 0.01); (b) the RGC of the patient without the scaffold shows an action potential; (c) the patient’s RGC on the 2D scaffold shows a repetitive action potential in response to the continuous current injection.