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. 2017 Apr 12;21(10):2503–2513. doi: 10.1111/jcmm.13171

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© 2017 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Protective effects of rhMG53 were related to hepatic apoptosis inhibition. Rats were subjected to HIR or sham operation with or without administration of rhMG53 via caudal vein and then samples were collected after liver reperfusion for 6 and 24 hrs. (A) Terminal deoxynucleotidyl transferase‐mediated nick‐end labelling (TUNEL) staining (×200) of liver; (B) Bax/Bcl‐2, caspase 3/cleaved caspase 3 and cytochrome c (Cyto‐c) protein expression; (C) percentage of TUNEL‐positive cells; (D and F) density analysis of Bax/Bcl‐2, caspase 3/cleaved caspase 3 and cytochrome c (Cyto‐c) protein expression. Date are mean ± SEM, n = 8/group, **P < 0.01. HIR, hepatic ischaemia/reperfusion; rhMG53, recombinant human MG53 protein.