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. 2017 Apr 12;21(10):2503–2513. doi: 10.1111/jcmm.13171

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© 2017 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Schematic of proposed signalling involved in protective effects of MG53 on HIR injury. Hepatocyte cell membrane was damaged by ischaemia/hypoxia and aggravated by reperfusion/reoxygenation. Apoptosis is a main cell death pathway of hepatocytes subjected to ischaemia/reperfusion or hypoxia/reoxygenation. MG53 could promote repair of damaged cell membrane anchored by dysferlin, accompanied with decrease of hepatocytes oxidative stress which was manifested by ROS generation‐caused lipid peroxidation, DNA damage and protein peroxidation.