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. 2017 Apr 6;21(10):2481–2490. doi: 10.1111/jcmm.13169

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© 2017 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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EGCG reverses the hypoacetylation of AcH3K9 near the proximal promoter of cTnI in ageing hearts. Acetylation levels of specific lysine 9 amino acid in H3 (AcH3K9) are detected near the promoter of cTnI. The values of the 3M group are standardized as 1. Values are expressed as mean ± S.D. from three separate experiments. Statistical significance was determined by anova followed by least significant difference (LSD) tests. *P < 0.05 as compared with the 18M + EGCG and 3M groups. EGCG: epigallocatechin‐3‐gallate.