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. 2017 Apr 13;21(10):2329–2343. doi: 10.1111/jcmm.13154

Figure 6.

Figure 6

Effects of low‐dose DHB treatment on Mclk1 KO mice. Whole‐body Mclk1 KO mice, generated by inducible Cre/loxP‐mediated gene excision 21, were given water containing different concentrations of DHB starting ~ 6 months after completion of KO induction. (A) Bodyweight of Mclk1 KO mice after 4 months of treatment with DHB. Error bars represent S.E.M. n = 3–5. *P < 0.05 versus bodyweight before start of treatment (Student's t‐test). (B) Days of survival after completion of KO induction. Data shown are mean survival values ± S.E.M. ***P < 0.0001, ****P < 0.00001 versus no treatment group (one‐way anova followed by Dunnett's test). (C) Pictures taken before and after 2 months of DHB treatment at the indicated doses.