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. 2017 Apr 19;21(10):2514–2523. doi: 10.1111/jcmm.13172

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© 2017 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Acute application of supraclinical concentrations of amiodarone and dronedarone inhibits I_k1 in rabbit left ventricular cardiomyocytes. (A) I_K1 current–voltage relationships of cardiomyocytes superfused with 5 μM (triangles, N = 6), 10 μM (squares, N = 7) and 50 μM (diamonds, N = 6) amiodarone (A) display dose‐dependent decreases in I_K1 reaching significance for 50 μM (at −120 and −110 mV) only. C depicts time‐matched controls (N = 10). (B) I_K1 current–voltage relationships of cardiomyocytes superfused with 1 μM (triangles, N = 5), 5 μM (squares, N = 8) and 20 μM (diamonds, N = 6) dronedarone (D) display dose‐dependent decreases in I_K1 reaching significance for 20 μM (at −120, −110 and −100 mV) only. C depicts time‐matched controls (N = 11). *P < 0.05.