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. 2017 Apr 19;21(10):2514–2523. doi: 10.1111/jcmm.13172

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© 2017 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Amiodarone and dronedarone induce dose‐dependent intracellular K_IR2.1 accumulation. (A) K_IR2.1‐GFP localization in control (C) (untreated) and HK‐KWGF cells treated for 24 hrs with 2 (D2) or 5 (D5) μM dronedarone, or 2 (A2), 5 (A5) or 10 (A10) μM amiodarone. (B) K_IR2.1 localization in control (C) (untreated) and END‐2, MES‐1 and EPI‐7 cells treated for 24 hrs with 10 (A10) μM amiodarone or 5 μM (D5) dronedarone. Scale bars represent 5 μm.