Figure 3.

The inflammasome inhibitor reduced the myocardial infarct size and decreased activation of the NLRP3 inflammasome, IL-1β, and caspase-1 (p10) in nondiabetic and diabetic rats after MI/R. The infarct size was detected by TTC staining (a). The CK-MB activities were determined by enzyme activity assay kits (b). The expression of NLRP3 (c), ASC (d), procaspase-1 and caspase-1 (e), and IL-1β (f) was analyzed by Western blot as shown. Data are expressed as the mean ± SD. n = 6 to 8. ^∗∗P < 0.01 versus IR.