Fig. 1. (A) Depiction of the all atom model of γ-secretase, derived from the 5FN2 PDB structure, colored by its subunits: PS1, NCT, PEN-2, and APH-1A in green, blue, yellow, and orange, respectively. (B) Fluctuation analysis of 5FN2-derived atomistic model of γ-secretase in POPC bilayer (gray) color-coded by the normalized per-residue root mean square fluctuation (RMSF) from more flexible (red) to less flexible (blue). The analysis was performed during the last 500 ns of the simulation.
