Skip to main content
. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Physiol Behav. 2016 Oct 25;172:49–59. doi: 10.1016/j.physbeh.2016.10.015

Fig. 1.

Fig. 1

Hypothesized anatomical pathways translating mPFC output into autonomic processes. Simplified direct connections are illustrated without indirect multisynaptic circuits. Glutamate outflow from the PL targets GABAergic neurons in the BST and both 5-HT and GABAergic cells in the raphe. These structures then provide direct input to preganglionic neurons of the parasympathetic and sympathetic nervous systems. The IL targets local GABAergic interneurons within the glutamatergic PH to gate stress responding. Additional glutamatergic IL efferents target the NTS, although the neurochemistry of these targets has yet to be determined. See text for references. PL: prelimbic cortex, BST: bed nucleus of the stria terminalis, DMV: dorsal motor nucleus of the vagus, NA: nucleus ambiguus, IML intermediolateral cell column, IL: infralimbic cortex, NTS: nucleus of the solitary tract, PH: posterior hypothalamus, Glu: glutamate, 5-HT: serotonin, ACh: acetylcholine.