Table 1.
Study results.
| Study, year | Participants N (male/female) |
Treatment applied =N |
Mean age (years) |
Duration of disease (years) | Follow-up (months) |
Number of assessments (period) |
|---|---|---|---|---|---|---|
| Burchiel et al., 1999 | 10 (7m/3f) |
DBS GPi=4 DBS Stn=6 |
56 | 12.1 | 0-12m | 5 (preop, 10 days, 3,6,12 months) |
| Daniels et al., 2011 | 121 (m/f=NI) |
DBS Stn=61 Med=60 |
59.7 | 13 | 0-6m | 2 (baseline ,6 months) |
| Deuschl et al., 2006 | 156 (100m/56f) |
DBS Stn=78 Med=78 |
60.6 | 13.4 | 0-6m | 2 (baseline ,6 months) |
| Deuschl et al., 2013 | 251 (m/f=NI) |
DBS Stn+Med=123 Med=123 |
52.6 | 7.5 | 0-24m | 3 (5,12,24 months) |
| Follet et al., 2010 | 299 (249m/50f) |
DBS GPi=152 DBS Stn=147 |
61 | 11.3 | 0-24m | 5 (3,6,12,18,24 months) |
| Gill et al., 2011 | 30 (27m/3f) |
Med=15 DBS Stn+Med=15 |
60 | 2.2 | 0-24 m | 5 (baseline, 6,12,18, 24 months) |
| Merello et al., 2008 | 16 (9m/7f) |
DBSStn+Sub=5 DBS Stn Bil=6 Sub Bil=5 |
0-12m | 3 (1,6,12 months) | ||
| Odekerken et al., 2013 | 128 (88m/38f) |
DBS Stn:63 DBS GPi:65 |
60 | 11 | 0-12m | 4 (1,3,6,12 months) |
| Okun et al., 2009 | 45 (m/f) |
DBS GPi=23 DBS Stn=22 |
60 | 13 | 0-7m | 2 (preop and 7 months) |
| Rocchi et al., 2012 | 66 (m/f=NI) |
HC=28 PDC=9 DBS Stn=15 DBS GPi=14 |
61 | 12 | 0-6 m | 3 (preop, baseline and 6 months) |
| Schubpach et al., 2007 | 20 (12m/8f) |
DBS Stn=10 Med=10 |
48 | 6.8 | 0-18m | 4 (preop, 6, 12, 18 months) |
| Smeding et al., 2005 | 34 (11m/23f) |
Palli=14 DBS Stn=20 |
61 | 11.5 | 0-12m | 3 (base, 6, 12 months) |
| Weaver et al., 2009 | 255 (206m/49f) |
DBS GPi=61 DBS Stn=60 med=134 |
62 | 11 | 0-6m | 2 (base, 6 months) |
| Weaver et al., 2012 | 156 (131m/25f) |
DBS GPi=89 DBS Stn=70 |
60.5 | 11 | 0-36m | 6 (3,6,12,18,24,36 months) |
| Weiss et al., 2013 | 12 (9m/3f) |
DBS Stn=6 DBS Stn+SNi=6 |
65 | >4.5 | 0-6 weeks | 3 (baseline, 3 and 6 weeks) |
| Williams et al., 2010 | 366 (256m/110f) | DBS Stn=183 Med=183 |
59 | 11.3 | 0-12m | 2 (baseline, 12 months) |
| Witt et al., 2008 | 123 (77m/46f) |
DBS Stn=60 Med=63 |
59.5 | 13.9 | 0-6 m | 2 (baseline, 6 months) |
| Witt et al., 2013 | 62 (28m/34f) |
DBS Stn=31 Med=31 |
59.3 | >5 | 0-6 m | 2 (baseline, 6 months) |
| Zahodne et al., 2009 | 42 (30m/12f) |
DBS GPi=22 DBS Stn=20 |
61.3 | 13 | 0-6m | 2 (baseline, 6 months) |
N: number of subjects; m: male; f: female; NI: not informed; DBS GPi: Deep Brain Stimulation of the globus pallidus internal; DBS Stn: Deep Brain Stimulation of subthalamic nucleus; DBS SNi: Deep Brain Stimulation of substantia nigra; Palli: Pallidotomy; Sub: Subthalamotomy; Bil: Bilateral; Med: Best Medical Treatment; HC: Healthy Control; PDC: Parkinson’s Disease Control; Preop: Presurgery; Baseline.