Table 1. . Selected list of recent and current clinical trials for pediatric brain tumors that have incorporated nonsurvival-based end points.

Reference or identifier	Tumor type	Intervention	Nonsurvival end points†	Assessment tool
Hummel et al. [16]	High-grade glioma and diffuse intrinsic pontine glioma	Bevacizumab	QoL	PedsQL
NCT00085735 (ACNS0331)	Standard-risk medulloblastoma	Radiation and chemotherapy	Neurocognition QoL	ALTE07C1 PedsQL
NCT01096368 (ACNS0831)	Ependymoma	Maintenance chemotherapy following induction chemotherapy and radiation therapy	Neurocognition	ALTE07C1
NCT01602666 (ACNS1123)	Localized primary CNS germinoma	Chemotherapy followed by radiation	Neurocognition	ALTE07C1
NCT02096471	Plexiform neurofibroma	MEK inhibitor PD-0325901	QoL	PedsQL-NF1 Module

^†Nonsurvival end points: Quality of life (QoL), neurocognitive or neurological functioning.

QoL: Quality of life.