Table 1.

Comparison of the two neuropathological staging systems for argyrophilic grain disease, as proposed by Saito et al. in 2004 and Ferrer et al. in 2008.

Staging system	Stage
	I	II	III	IV
Saito et al., 20042	Ambient gyrus and its vicinity	I + anterior and posterior medial temporal lobe, including the temporal pole, as well as the subiculum and entorhinal cortex	II + septum, insular cortex and anterior cingulate gyrus, and spongy degeneration of the ambient gyrus	Moderate to severe additional involvement of the neocortex and brainstem
Ferrer et al., 20085	Anterior entorhinal cortex; mild involvement of the cortical and basolateral nuclei of the amygdale and of the hypothalamic lateral tuberal nucleus	more severe involvement of the nuclei involved in stage I + Entorhinal and transentorhinal cortices; anterior CA1	II + mild involvement of CA2, CA3, presubiculum; other nuclei of the amygdala; dentate gyrus, other nuclei of the hypothalamus, temporal, orbitofrontal and insular cortices, cingulated gyrus, ncl. accumbens, septal nuclei; midbrain