Figure 3.

Structural dynamics of ligand and substrate free 15-LOX-2. (A) Backbone amide deuteration levels of 15-LOX-2 peptides following incubation for 1 h in D₂O are mapped onto the crystal structure (PDB entry 4NRE)¹⁶ to provide information about the general flexibility and solvent exposure. Gray indicates regions that could not be identified. Peptides mentioned in this paper are designated by their sequence range. (B) Deuterium levels of the five helices that form the active site and coordinate the catalytic iron are shown. Helices are labeled by their numerical order in LOXs.