Table 2.

Studies that included moderate (beginning confluent; smooth halo) WMH and/or less than 5 lacunes required for diagnosis of SVD.

Author, year	N	Groups	Clinical criteria for MCI	Neuroimaging criteria for SVD	Neuropsychological tests
Norlund et al., 2007	180	NC, VaMCI, non-VaMCI	Subjective and objective cognitive impairment for more than 6 months not demented.	Moderate WMH or 2 or more lacunes	Visual Object and Space Perception, Assessment of Subtle Language Deficits, Parallel Serial Mental Operations, TMT
Gainotti et al., 2008	142	NC, VaMCI, non-VaMCI	Long-term Memory performance < 2 scores from cutoff, no cognitive impairment in non-memory domains, preserved functional status	2 or more subcortical infarcts (below 2 cm of size) or 1 subcortical infact + periventricularWMH of any size	RAVLT, Rey-Osterreith Complex Figure, Digit and Spatial Span, phonological and categorical verbal fluency, Raven's Standard Progressive Matrices, Multiple Features Targets Cancellation, Vill's test for temporal rule induction, Stroop interference test
Zhou et al., 2009a	156	NC, VaMCI, non-VaMCI	Cognitive impairment + CDR=0.5 + unimpaired ADL	Wahlund scale ≥ 2 or more than 2 lacunes	MMSE, Digit Span Backwards and Forward, WHO-UCLA AVLT, Rey-Osterreith Complex Figure, Stroop, Semantic Verbal Fluency, WAIS-RC, California Card Sorting Test, CDT
Zhou et al., 2009b	160	NC, VaMCI	Cognitive impairment + CDR=0.5 + unimpaired ADL	Wahlund scale ≥ 2 or more than 2 lacunes	MMSE, Digit Span Backwards and Forward, WHO-UCLA AVLT, Rey-Osterreith Complex Figure, Stroop, Semantic Verbal Fluency, WAIS-RC, California Card Sorting Test, CDT
Norlund et al., 2011	216	VaMCI, non-VaMCI, VaMCI and non-VaMCI with and without biological markers	Cognitive complaint+ objective cognitive decline + not demented + unimpaired ADL	Moderate WMH or 2 or more lacunes	Digit Symbol, TMT, Digit Span, RAVLT, Wechsler's Logical Memory, Rey-Osterreith Complex Figure, Visual Object and Space Perception, Block Design, Token Test, Boston Naming, Semantic Verbal Fluency, Parallel Serial Mental Operations, Dual Task, Stroop, Wisconsin Card Sorting Test, Cognitive Estimation Test
Marra et al., 2011	135	VaMCI, non-VaMCI	subjective and objective cognitive deficits (worse than 1.67 SD from normal values) and normal functional status	Fazekas ≥ 2 or more than 3 lacunes; or Periventricular WMH grade 1 + 2 or more lacunes	Rey's Auditory Verbal Learning Task, Rey-Osterrieth complex figure, Stroop, Multiple Features target cancellation, Phonological and Semantic Verbal Fluency, Raven's Progressive Matrices
Villeneuve et al., 2011	72	NC, MCI with WMH and MCI without WMH	Subjective cognitive complaint + cognitive performance 1.5 SD below normative values + preserved ADL	Wahlund ≥ 2	Mémoria computerized battery, BEM-144, RL/RI word recall Task, Rey-Osterrieth complex figure, Stroop, WAIS-III, Boston Naming Test, Benton judgment of line orientation test
Yi et al., 2012	54	NC, VaMCI	Subjective cognitive complaints, objective cognitive impairments, not demented (DSM-IV), normal ou near-normal functionbal status, CDR= 0.5, MMSE≥ 24.	Moderate to severe WMH in at least 1 region with a Wahlund rating scale score ≥2 and/or multiple pericentricular and deep lacunes	MMSE, AVLT
Sudo et al., 2013	36	NC, VaMCI	Impairment of 1.5 SD below the mean on 1 or more cognitive tests in relation to normative values, preserved or mildly impaired functional activities, (FAQ <5)	Moderate or severe degree of WMH on Fazekas scale and hippocampal atrophy ≤1 on de Leon score (none or questionable atrophy)	MMSE, CAMCOG, CDT, TMT, Semantic Verbal Fluency, Boston Naming Test
Brookes et al., 2015	503	VaMCI, CVD without cognitive impairment	scoring ≤1.5 SD of the normal mean on a given test	lacunar infarcts or lacunar infarcts with leukoaraiosis (Fazekas≥2)	Brief Memory and Executive Test (BMET), MMSE, MoCA