Table 1.

Demographic, clinical, neuroimaging and CSF data for each patient.

	AJP	CN	LD	MJJ	MY	PM	RD	TA
Sex	Male	Male	Male	Male	Male	Male	Male	Female
Age at evaluation (years)	68	68	56	72	76	62	57	49
Age at onset (years)	59	62	54	70	73	58	55	48
Family history of AD	No	No	No	No	Yes	No	Yes	No
Behavioral symptoms	Apathy, gluttony, collectionism, obsessions, neglect of personal self-care	Apathy, aggressive behavior, motor stereotypies, indifference, desinhibition	Motor stereotypies, aggressive behaviour, logopenia, anosognosia	Apathy, anosognosia, decline in social interpersonal conduct	Joviality, desinhibition, decline in social interpersonal conduct	Apathy, gluttony, aggressive behaviour, obsessions, neglect of personal self-care, logopenia	Joviality, desinhibition, decline in social interpersonal conduct, anosognosia	Affective indifference, apathy, social withdrawal
Brain MRI	Not performed (normal CT scan)	Global cortical atrophy	Frontal atrophy	Frontal atrophy	Global cortical atrophy	Global cortical atrophy	Global cortical atrophy	Frontal atrophy
SPECT	Marked frontal hypoperfusion	Marked frontal hypoperfusion	Marked frontal hypoperfusion	Marked frontal hypoperfusion	Marked frontal hypoperfusion	Marked frontal hypoperfusion	Marked frontal hypoperfusion	Marked frontal hypoperfusion
Aβ42	210	230	186	317	125	167	412	329
Tau	386	357	648	1064	504	1200	1200	1200
P-Tau	76	70	97	138	84.5	159	202	140
Tau/Aβ42	1.84	1.55	3.48	3.36	4.03	7.19	2.91	3.65
P-Tau/Aβ42	0.36	0.30	0.52	0.44	0.68	0.95	0.49	0.43