Table 2.

Abnormalities in the gastrin-releasing peptide receptor (GRPR) pathway in patients with Alzheimer's disease (AD).

Finding	References
Enhanced bombesin (BB)-induced calcium release in fi brobasts	[23, 24]
Reduced BB-induced calcium mobilization in fibrobasts in patients with the Swedish APP670/671 mutation	[21]
Increased response of BB-induced calcium release to oxidant agents in patients with presenilin-1 (PS-1) mutation	[23]
Reduced number of gastrin-releasing peptide receptors (GRPRs) in fi broblasts	[24]