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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: IUBMB Life. 2017 Mar 8;69(4):263–270. doi: 10.1002/iub.1613

Figure 2. Schematic representation of factors in NAFLD etiology.

Figure 2

Interactions between Cu deficiency and fructose may contribute to NASH. While obesity and associated lipotoxicity of liberated free fatty acids are commonly attributed as drivers of NASH after the development of steatosis, copper deficiency and fructose consumption may promote lipogenesis, oxidative stress, inflammation and hepatic stellate cell activation, compounding the progression of NAFLD. Abbreviations: FA, fatty acids; FFA, free fatty acids.