TABLE 2.
Behavioral Problems Associated With FXS+ASD and FXS Only, by Age Group, in Subjects Enrolled From September 7, 2012 Through August 31, 2014, FORWARD Database
| Ages 3–11 y | Ages 12–21 y | |||||
|---|---|---|---|---|---|---|
| Does the Child Currently Have This Behaviora: N (%) | FXS+ASD (N = 144) | FXS Only (N = 199) | P | FXS+ASD (N = 90) | FXS Only (N = 109) | P |
| Attention problems | 126 (88) | 153 (77) | <.01b | 81 (90) | 84 (77) | <.02b |
| Anxiety | 120 (83) | 149 (76) | <.08 | 87 (98) | 93 (87) | <.006b |
| Hypersensitivity/overreaction to stimuli/emotionally reactive | 114 (82) | 130 (66) | <.001b | 74 (87) | 60 (56) | <.001b |
| Hyperactivity | 108 (75) | 126 (63) | <.02b | 57 (65) | 44 (40) | <.001b |
| Irritability/aggression/agitation/self-injury | 103 (72) | 76 (38) | <.001b | 63 (71) | 39 (37) | <.001b |
| Obsessive compulsive disorder/perseverative behavior | 95 (67) | 87 (44) | <.001b | 64 (72) | 56 (53) | <.006b |
| Mood swings/depression | 22 (16) | 29 (15) | <.79 | 22 (25) | 22 (21) | <.51 |
FORWARD is a data set of clinician and parent-report information from specialty clinics in the FXCRC. χ2 tests for association were used to obtain P values for differences in proportions between case groups for use of services.
a
Responses to this question were inconsistently answered among clinicians; 60% responded for behavior with the patient on medication and 40% responded for behavior when the patient was not on medication.
b
Significant P value (a level of .05 was considered statistically significant).