Fig 3. Summary of between-pathway and within-pathway interactions discovered from the phs000812 (BPC3) cohort.

(A) Network representation of a set of significant (FDR ≤ 0.25) pathway-level interactions (BPM, WPM and PATH) that are associated with increased risk of breast cancer. Node size reflects the interaction degree. (B & C) Heatmap view of the interaction between the Acute Myeloid Leukemia (AML) gene set and the steroid hormone biosynthesis (SHB) pathway in the discovery cohort BPC3 (B) and in the replication cohort CGEMS (C). Red in the heatmap indicates that there is at least one SNP-SNP interaction identified between the corresponding genes.