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. 2017 Sep 28;12(9):e0184451. doi: 10.1371/journal.pone.0184451

Fig 7. Immunohistochemical staining of mouse tissues after orthotopic transplantation of cultured MTFs.

Fig 7

Human MTFs were cultured from blood as described, and orthoptically transplanted into mouse pancreas. After various periods of time, tissues were harvested and stained for an epithelial marker (cytokeratin, KRT), human macrophage M2 polarization markers CD204 and CD206, and human pancreatic stem cell marker ALDH1A1. Tissues (pancreas, spleen, and liver) are as indicated. Panel A shows samples harvested at 4 weeks after implantation, B shows samples after 8 weeks, and C shows samples after 12 weeks.