Table 1. Description of cell-specific models based on cell lineage from Fig 1.

Each candidate model corresponds to a partition of cell types into non-overlapping groups. Cell types within each set of parentheses, {}, belong to the same partition and were assumed to have the same level of methylation. For each cell-specific model excluding ‘All’, the partition annotated by an asterisk (*) denotes the reference partition.

Candidate Model	Differentially methylated cell type(s)	Partition
Lymphocyte-I	All Lymphocytes	{CD19+},{CD4+},{CD8+},{CD56+},{CD14+,CD16+}*
Lymphocyte-II	Lymphocytes excl. CD19+ B cells	{CD4+},{CD8+},{CD56+},{CD19+,CD14+,CD16+}*
Myeloid	All Myeloids	{CD14+},{CD16+},{CD19+,CD4+,CD8+,CD56+}*
Pan T	T cells	{CD4+},{CD8+},{CD19+,CD56+,CD14+,CD16+}*
CD19+ B	CD19+ B cells	{CD19+},{CD4+,CD8+,CD56+,CD14+,CD16+}*
CD4+ T	CD4+ T cells	{CD4+},{CD19+,CD8+,CD56+,CD14+,CD16+}*
CD8+ T	CD8+ T cells	{CD8+},{CD19+,CD4+,CD56+,CD14+,CD16+}*
CD56+ NK	CD56+ Natural Killers	{CD56+},{CD19+,CD4+,CD8+,CD14+,CD16+}*
CD14+ Mono	CD14+ Monocytes	{CD14+},{CD19+,CD4+,CD8+,CD56+,CD16+}*
CD16+ Neu	CD16+ Neutrophils	{CD16+},{CD19+,CD4+,CD8+,CD56+,CD14+}*
All	All available cell types	{CD19+},{CD4+},{CD8+},{CD56+},{CD14+},{CD16+}
Null	None	{CD19+,CD4+,CD8+,CD56+,CD14+,CD16+}