Table 3. Crude mortality rate and relative adjusted Hazard Ratio for 9 years principal causes of death (cardiovascular disease, cancer, and other causes) in 1044 community dwelling older individuals enrolled into the INCHIANTI study according to combined levels of LDL-C and HDL-C.
| 9 YEARS MORTALITY | ||||
|---|---|---|---|---|
| CVD | CANCER | OTHER | ||
| GROUP 1 (n = 470) | Crude rate | 17.6/1000/person-year | 5.3/1000/person-year | 10.1/1000/person-year |
| High LDL-C | ||||
| Normal HDL-C | Hazard Ratio | 1 | 1 | 1 |
| GROUP 2 (n = 117) | Crude rate | 26.7/1000/person-year | 9.3/1000/person-year | 10.4/1000/person-year |
| High LDL-C | ||||
| Low HDL-C | Hazard Ratio | 1.08 (CI: 0.63–1.83) | 1.77 (CI: 0.76–4.12) | 0.64 (CI: 0.27–1.55) |
| GROUP 3 (n = 331) | Crude rate | 24.0/1000/person-year | 13.7/1000/person-year | 20.3/1000/person-year |
| Optimal/near optimal LDL-C | ||||
| Normal HDL-C | Hazard Ratio | 0.96 (CI: 0.65–1.41) | 2.49 (CI: 1.38–4.49) | 1.41 (CI: 0.87–2.27) |
| GROUP 4 (n = 126) | Crude rate | 28.1/1000/person-year | 26.9/1000/person-year | 28.1/1000/person-year |
| Optimal/near optimal LDL-C | ||||
| Normal HDL-C | Hazard Ratio | 0.75 (CI: 0.41–1.37) | 4.52 (CI: 2.30–8.86) | 1.59 (CI: 0.78–3.21) |
H.R. adjusted for: age, gender, statin therapy, years of school, smoking, alcohol consumption, BMI, creatinine, uric acid, IL-6 plasma levels, serum albumin, hypertension, diabetes, CHD, stroke, CHF, weight loss >4.5 kg in the last year, and diagnosis of cancer.