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. 2017 Sep 28;12(9):e0185607. doi: 10.1371/journal.pone.0185607

Table 1. Clinical and histopathological characteristics of the total MATCH cohort.

n % SYK(T)
median (IQR)
P value SYK(S)
median (IQR)
P value SYK(L)
median (IQR)
P value Performed test
Gender Female 112 46.7% -4.24 (-4.60 • -3.72) 0.11 -4.81 (-5.47 • -4.14) 0.18 -4.76 (-5.16 • -4.17) 0.40 Mann-Whitney U
Male 128 53.3% -4.05 (-4.58 • -3.50) -4.63 (-5.27 • -3.93) -4.66 (-5.19 • -4.03)
Age 240 100% -0.08 0.21 -0.009 0.89 -0.011 0.86 Spearman's Rho
Tumor stage Stage I 60 25.0% -4.31 (-4.71 • -3.67) 0.31 -4.62 (-5.21 • -3.96) 0.037 -4.73 (-5.26 • -4.28) 0.45 Jonckheere-Terpstra
Stage II 100 41.7% -3.96 (-4.55 • -3.47) -4.61 (-5.36 • -4.07) -4.54 (-5.04 • -3.95)
Stage III 80 33.3% -4.15 (-4.58 • -3.68) -4.98 (-5.70 • -4.19) -4.81 (-5.30 • -4.33)
T status T2 71 29.6% -4.32 (-4.69 • -3.76) 0.03 -4.69 (-5.26 • -3.97) 0.37 -4.77 (-5.33 • -4.46) 0.021 Mann-Whitney U
T3 169 70.4% -4.05 (-4.57 • -3.56) -4.70 (-5.43 • -4.08) -4.65 (-5.11 • -4.04)
Nodal status N0 ≥ 10 nodes assessed 131 54.6% -4.08 (-4.60 • -3.62) 0.97 -4.63 (-5.32 • -4.08) 0.07 -4.62 (-5.13 • -4.04) 0.037 Jonckheere-Terpstra
N0 < 10 nodes assessed 29 12.1% -3.81 (-4.66 • -3.43) -4.30 (-5.28 • -3.74) 4.68 (-5.17 • -3.90)
N1 53 22.1% -4.09 (-4.48 • -3.64) -4.89 (-5.68 • -4.21) -4.77 (-5.34 • -4.38)
N2 27 11.3% -4.30 (-4.60 • -3.69) -5.08 (-5.74 • -4.03) -4.96 (-5.21 • -4.31)
Tumor grade Good 20 8.3% -3.95 (-4.43 • -3.46) 0.57 -4.61 (-5.30 • -3.88) 0.28 -4.59 (-4.81 • -3.97) 0.61 Jonckheere-Terpstra
Moderate 192 80.0% -4.14 (-4.60 • -3.61) -4.69 (-5.33 • -4.08) -4.72 (-5.20 • -4.15)
Poor 20 8.3% -4.10 (-4.60 • -3.74) -4.95 (-5.87 • -4.35) -4.78 (-5.24 • -4.08)
Other 8 3.3% -3.94 (-4.62 • -3.53) -4.30 (-5.79 • -3.79) -4.48 (-4.86 • -4.03)
Location Right 121 50.4% -4.24 (-4.71 • -3.70) 0.015 -4.89 (-5.58 • -4.15) 0.004 -4.84 (-5.28 • -4.28) 0.008 Mann-Whitney U
Left 119 49.6% -4.01 (-4.47 • -3.53) -4.52 (-5.21 • -3.85) -4.62 (-4.96 • -4.13)
MSI statusa MSI 49 20.4% -4.59 (-5.02 • -4.25) <0.001 -5.34 (-5.77 • -4.86) <0.001 -5.05 (-5.49 • -4.54) <0.001 Mann-Whitney U
MSS 190 79.2% -3.96 (-4.47 • -3.49) -4.46 (-5.21 • -3.92) -4.63 (-5.08 • -4.03)

SYK mRNA expression levels were normalized using the average of three reference genes (HMBS, HPRT1 and TBP) using the 2-ΔΔCq method as described in detail before by Livak and Schmittgen [21] and Sieuwerts et al [22].

a n = 1 missing