Fig 3. CCHFV-specific IgG ELISA titers increase following each vaccination.
The CCHFV-specific ELISA titers following three vaccinations are similar in IFNAR-/- and WT C578BL/6 mice before challenge. A) Mouse sera were pooled in each vaccination group and the CCHFV-specific IgG antibodies were measured by CCHFVLP ELISA following each vaccination with the optimized CCHFV-M vaccine. Vaccinations were performed at weeks 0, 3, and 6. B) The CCHFV IgG ELISA titers for individual mice 1 week prior to challenge; mice that died after CCHFV challenge are shown in red. *One-way ANOVA, confidence intervals were set to 95%.